Why is Mobility Plus the best choice you will make for your pet and how can each ingredient help your pet to enjoy life to the fullest?
- Glucosamine and Chondroitin work together to help ensure that your pet's body is well equipped to produce adequate proteoglycans, and that there is enough synovial fluid to flow as needed. To read more about proteoglycans and synovial fluid, click HERE.
- Hyaluronic acid works to help encourage synovial fluid supply.
- MSM (Methylsulfonylmethane) is added to tackle muscle pain and inflammation. A powerful source of elemental sulfur, MSM is especially helpful when used in conjunction with glucosamine and chondroitin.
- Yucca acts as a powerful natural anti-inflammatory agent. It contains polyphenols and saponins, is a terribly efficient antioxidant free radical scavenger and compliments our other ingredients beautifully.
- DHA Omega-3 fatty acidsare terrific for skin and coat, immune function, and also inflammation. This is why we add a healthy dose to each Mobility Plus tablet. DHA is also important for cognitive health, and with older animals, this is surely a good thing to preserve in any way we can!
Ascorbic Acid for uptake and immune system support. Important in the production of collagen which is needed for soft-tissue support for joints.
- Zinc helps the body utilize antioxidants and is important for uptake
Pine bark extract is something truly special: A powerful anti-inflammatory agent and source of Oligomeric Proanthocyanidin Complexes (OPC’s). Our pine bark extract contains 95% proanthocyanidins. This is important, as not all pine bark extract is the same. OPC’s act as powerful anti-inflammatory agents by inhibiting the enzyme cyclooxygenase, and is beneficial for your pet's circulation. In addition, OPC’s enhance T-helper cells (T-lymphocytes), which are essential to fighting autoimmune diseases as well as cancer.
In short, osteoarthritis occurs on joint surfaces at the point where contact is most prevalent. Over time, hyaline cartilage which cushions joints can completely wear away. Cartilage consists mainly of the glyco-protein material chondroitin and also the amino sugar glucosamine, a natural compound also found in connective tissue, bones and bone marrow. As animals age, they also stop producing an adequate supply of synovial fluid which lubricates the joints. The result is that the affected joint no longer has adequate cushion or lubrication, and it begins to rub bone-on-bone. This can cause significant pain and loss of motion.
What we DON'T do:
won't find some ingredients which may be good for some animals but not
for others (like bosweilla or devil's claw, commonly found in other formulas) . You won't find "token"
ingredients in no measurable therapeutic quantity. And when you call us?
You won't find a phone bank or a salesperson who is only interested in
making a sale. You will find an animal lover who is genuinely concerned
about YOUR pet's health. We will never, ever try to talk you in to
something you don't need and if you need something other than what we
can offer, we will gladly help you find what you do. That's just the way
each tablet contains:
Yucca Extract (4:1)*...........75m
DHA Omega-3 Powder.......35mg
Ascorbic Acid (Vitamin C)...25mg
Pine Bark Extract*..............15mg
*Not recognized as an essential nutrient by AAFCO dog and cat nutrient profiles)
Terrific ingredients sourced for potency and safety, a delivery system which not only ensures proper uptake and absorption, but tastes like a treat to most pets, and a manageable price point and dose. We should call it Mobility Plus Plus Plus!
If you would like to talk more about any of our products, or about anything else for that matter, please drop us a line. We would love to hear from you!
Supporting Research on the active ingredients in Mobility Plus:
Glucosamine, Chondroitin and MSM:
American Journal of Veterinary Research 1999 Dec;60(12):1552-7: Canapp SO Jr, McLaughlin RM Jr, Hoskinson JJ, Roush JK, Butine MD:Evaluation of Glucosamine HCI and Chondroitin Sulfate as Treatment for Acute Synovitis in Dogs
Clinical Drug Investigation 2004: 24:353-363.: P.R. Usha and M.U.R Naidu: Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane (MSM) and their combination in osteoarthritis
Am J Vet Res. 1999 Dec;60(12):1552-7.Canapp SO Jr, McLaughlin RM Jr, Hoskinson JJ, Roush JK, Butine MD: Scintigraphic evaluation of dogs with acute synovitis after treatment with glucosamine hydrochloride and chondroitin sulfate.
International Journal of Anti-Aging Medicine, Summer 1998, I (I);50: Ronald M. Lawrence MD,PhD: Methyl-Sulfonyl-Methane (MSM) A Double Blind of its use in Degenerative Arthritis
Oligomeric Proanthocyanidins (GSE and Pine Bark Extract)
Biotechnol Ther 1994; 5:117-26:Rong Y, Li L, Shah V, Lau BH. Pycnogenol protects vascular endothelial cells from t-butyl hydroperoxide induced oxidant injury.
Redox Report 1997; 3:219-24:Wei Z, Peng Q, Lau B. Pycnogenol enhances endothelial cell antioxidant defenses.
FEBS Lett 1998; 431:315-8: Virgili F, Kim D, Packer L. Procyanidins extracted from pine bark protect alphatocopherol in ECV 304 endothelial cells challenged by activated RAW 264.7 macrophages: role of nitric oxide and peroxynitrite.
Drug Devel Industr Pharm 1998; 24:139-44Nelson A, Lau B, IDe N, Rong Y. Pycnogenol inhibits macrophage oxidative burst, lipoprotein oxidation, and hydroxyl radical induced DNA damage.
Path Biol 1990; 38:601-7: Robert A, Groult N, Six C, Robert L. Study of the effect of procyanidolic oligomers on mesenchymal cells in culture. II Attachment of elastic fibers to the cells.
Path Biol1990;6: Robert L, Godeau G, Gavignet-Jeannin C, Groult N, Six C, Robert A. Action of procyanidolic oligomers on vascular permeability. A study by quantitative morphology.
Omega-3 Fatty Acids
Prostaglandins Leukot Essent Fatty Acids. 2005 Nov;73(5):335-41.: Hall JA, Henry LR, Jha S, Skinner MM, Jewell DE, Wander RC. Dietary (n-3) fatty acids alter plasma fatty acids and leukotriene B synthesis by stimulated neutrophils from healthy geriatric Beagles.
Journal of Nutritional Biochemistry. 2007 May 23:Hansen RA, Harris MA, Pluhar GE, Motta T, Brevard S, Ogilvie GK, Fettman MJ, Allen KG: Fish oil decreases matrix metalloproteinases in knee synovia of dogs with inflammatory joint disease
While there are no double blind studies on the effectiveness of Yucca, we do know that yucca is safe to give to companion animals, and that the polyphenols and saponins contained in yucca are effective antioxidants and free radical scavengers. More clinical studies are in progress and we will update this information as it becomes available.
Journal of Agricultural Food Chemistry: Oleszek W, Sitek M,
Stochmal A, Piacente S, Pizza C, Cheeke P.Resveratrol and other
phenolics from the bark of Yucca schidigera roezl.
Journal of Applied Nutrion 1975;27:45 51:Bingham R, Bellow BA, Bellow JG: Yucca plant saponin in the management of arthritis.
From USDA Agricultural Research Service: Botanicals Generally Recognized as Safe. http://www.ars-grin.gov/duke/syllabus/gras.htm
American Journal of Clinical Nutrition: 2005 Jan;81(1 Suppl):215S-7S: Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond.
Journal of Inflammation (London ed). 2006 March. PR Cheeke, Piacente W Oleszek: Anti-inflammatory and anti-arthritic effects of Yucca schidigera: a review.
note: while studies abound regarding injectable HA, we are interested in and have include studies on the affects of oral administration, since that is how we use it.
Tissue Cell 2004;36:431-438. Hegewald A, Ringe J, Bartel J, et al. Hyaluronic acid and autologous synovial fluid induce chondrogenic differentiation of equine mesenchymal stem cells: a preliminary study.
Journal of Agricultural Food Chemistry 2008, 56, 10582–10593: Balogh L, Polyak A, Mathe D, Kiraly R, Gyozo J, Schauss AG, and Bucci LR: Absorption, Uptake and Tissue Affinity of High-Molecular Weight Hyaluronan after Oral Administration in Rats and Dogs.
Seminars in Arthritis and Rheumatism: 2000 Oct; 30(2 Suppl): 19-25Dougados, M. Sodium Haluronate Therapy in Osteoarthritis: Arguments for a Potential Beneficial Structural Effect.
Ascorbic Acid (Vitamin C)
Gropper SS, Smith JL, Grodd JL (2004). Advanced Nutrition and Human Metabolism (4th ed.). Belmont, CA. USA: Thomson Wadsworth. pp. 260–275.
Levine M, Rumsey SC, Wang Y, Park JB, Daruwala R (2000). "Vitamin C". In Stipanuk MH. Biochemical and physiological aspects of human nutrition. Philadelphia: W.B. Saunders. pp. 541–67.
Preedy VR; Watson RR; Sherma Z (2010). Dietary Components and Immune Function (Nutrition and Health). Totowa, NJ: Humana Press.