Cat and Dog Immune Support Formula Details

Having a pet that is happy and healthy begins by providing your furry friend with the nutrients that they need. Tons of nutrients are found in dog food, but more often than not, foods don’t contain all of the ingredients your pet needs to be healthy, and even if they do it isn’t always enough. If your pet’s immune system is currently struggling to fight back illness, adding EnduraPet’s immune support supplement is exactly what they need. When we set out to find an immune supplement that would help our beloved pets fight back, we had done the research to know exactly what ingredients would help promote their immune system even in the face of serious disease.

 

60 tablets per bottle 

Usage:  GUARANTEED ANALYSIS
Recommended Daily Dosage
each tablet contains:
Up to 20 pounds......1/2 to 1 tablet per day

 

L-Lysine HCL...............................................250 mg

21-49 pounds..........2 tablets per day

 

Vitamin E (succinate)...................................10IU

over 90 pounds.......4 tablets per day

 

Omega-3Fatty Acids (min 6.5% DHA)*......500 mg

50-90 pounds..........3 tablets per day

 

Maitake mushroom*...................................50 mg

over 90 pounds.......4 tablets per day

 

Green tea extract *......................................40 mg

 

 Raspberry seed extract*( 5mg ellagitannins).25 mg

 

Pine Bark/Grape Seed Extract (guaranteed 95% OPC).10 mg

 

N-Acetyl-Cysteine* ......................................20 mg

 

Coenzyme Q10*...........................................15 mg

 

(*Not recognized as an essential nutrient by AFCO dog and cats food nutrient profiles)

 

 

Ingredient   

 Benefit

 

 

 

L-Lysine HCL

 

 

L-Lysine is an essential amino acid that helps your pet's body produce antibodies, hormones, and enzymes that boost the immune system. It also helps with calcium absorption (for strong bones) and collagen production (for healthy skin). Dogs and cats with chronic viral infections have responded extremely well to L-Lysine, particularly cats who have FIV or feline herpes virus.

 

 

 

Vitamin E (Succinate)

 

 

 

Many supplements include Vitamin E alpha-tocopheryl acetate, but our supplement uses Vitamin E succinate, the only form of Vitamin E that has been shown to inhibit the proliferation and promote apoptosis (natural cell death) of cancer cells. It also appears to decrease the toxicity of normal, non-cancerous cells. Vitamin E succinate helps cancer cells revert back to their normal state and induces cancer cell death. It is also more easily accumulated in cancer cells.

 

 

 

 

 

Omega-3 Fatty Acids

 

 

 

 

MMP enzymes make pets more susceptible to cancer by assisting in cell wall division. Omega-3 fatty acids inhibit those enzymes as well as reducing secretion of several cytokines that promote tumor growth, including tumor necrosis factor a (TNF-a), interleukin 1B (IL-1B), IL-1a and IL-2. Omega-3 fatty acids are also much more difficult for cancer cells to use for energy. Animal studies suggest that Omega-3s may prevent or reduce cancer-related weight loss, appetite loss, and muscle wasting (collectively known as cachexia). In addition to its cancer-fighting properties, Omega-3 fatty acids are also recommended for pets with heart disease, kidney disease, arthritis, and skin allergies.

 

 

 

Maitake Mushroom

 

 

Medicinal mushrooms have been used successfully for thousands of years. They contain beta-glucans which provide powerful polysaccharide compounds that have anti-viral and anti-tumor properties. Studies show that of all medicinal mushrooms, Maitake appears to be the most effective of all the medicinal mushrooms for pets with cancer. And it just so happens that most pets love the way they taste.

 

 

Green Tea Extract (decaffeinated)

 

 

A powerful antioxidant, green tea contains Epigallocatechin Gallate (EGCG) which has been shown to help with autoimmune diseases, cancer, and regulating viral load. Though there are many studies showing the beneficial effects of green tea on humans, feeding GTE to pets is considered optimal, as heating the leaves may completely eliminate their autoimmune disease-and cancer-fighting properties.

 

 

Raspberry Seed Extract

 

 

 

Raspberry seed extract contains ellagic acid, which is a micro-nutrient contained in the seeds. Research shows that cancer cells exposed to ellagic acid do not survive and undergo a natural cell death. Each of our tablets contains 5 mg of ellagitannins, making this ingredient an extremely powerful cancer-fighting addition. Raspberry seed extract also provides anti-inflammatory benefits.

 

 

 

 

Pine Bark Extract

 

 

 

Oligomeric Proanthocyanidins (OPC’s) ) are found in Grape seed extract and pine bark extract. OPCs enhance T-helper cells (T-lymphocytes), which are essential to fighting autoimmune diseases as well as cancer. T-helper cells destroy virally infected cells as well as tumor cells. GSE also contains powerful anti-inflammatory agents by inhibiting the enzyme cyclooxygenase, and is beneficial for your pet's circulation. Not all extracts are created equal, and we always test to ensure the GSE and PBE we purchase contains at least 95% OPC concentration.

 

 

 

N-Acetyl-Cysteine

 

 

 

Cysteine is rapidly metabolized to glutathione, which acts as a powerful antioxidant and detoxifier in the body. Glutathione does not work well through direct supplementation; however, when it is metabolized from cysteine it is very effective in detoxifying harmful chemicals in the body. Recent studies have shown that cysteine stimulates the production of T4 white blood cells, which protect the immune system and are essential to fighting cancer and other autoimmune diseases.

 

 

 

Coenzyme Q10

 

 

CO-Q10 is a potent antioxidant and is often included in supplements, but unfortunately we have rarely found it offered in the correct therapeutic levels in tandem with other essential immune system-supporting ingredients. It helps prevent free radicals from damaging healthy cells and is tremendously helpful for immune stimulation. It is also excellent for periodontal (gum) care and essential for overall energy.

 

Note: Unlike most other natural immune support supplements for pets, we do NOT include the herb milk thistle. Milk thistle is wonderfully hepatoprotective for animals with compromised liver function, and we wholeheartedly advocate using it for animals who need it. The risk when not needed is that it can be so effective it can actually overprotect healthy livers, and can reduce healthy liver function.

(IMPORTANT: While it is never recommended to feed dogs grapes, it is the skin and pulp of grapes (or anything in the currant family) which must be avoided, not the seeds. Grapeseed extract is safe and extremely beneficial for both dogs and cats!)

 

Supporting Research on the Active Ingredients in EnduraPet Immune Support:

L-Lyseine

American Journal of Veterinary Research 64:1, 37-42 : David J. Maggs , Mark P. Nasisse , Philip H. Kass . (2003) Efficacy of oral supplementation with L-lysine in cats latently infected with feline herpesvirus.

American Journal of Veterinary Research 70:11, 1391-1400 (2009) : Tracy L. Drazenovich, Andrea J. Fascetti, Hans D. Westermeyer, Jane E. Sykes, Mike J. Bannasch, Philip H. Kass, Kate F. Hurley, David J. Maggs. Effects of dietary lysine supplementation on upper respiratory and ocular disease and detection of infectious organisms in cats within an animal shelter.

American Journal of Veterinary Research,2002;63;99-103 Jean Stiles, DVM,MS; Wendy Townsend DVM;Quinton M. Rogers, PhD; Sheryl G. Krohne,DVM,MS: Effect of Oral administration of L-Lysine on conjunctivitiscaused by feline herpesvirus in cats


Vitamin E Succinate:

Clinical Cancer Research, journal for the American Association for Cancer Research 2002 Mar;8(3):863-9:Weber T, Lu M, Andera L, Lahm H, Gellert N, Fariss MW, Korinek V, Sattler W, Ucker DS, Terman A, Schröder A, Erl W, Brunk UT, Coffey RJ, Weber C, Neuzil J: Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo.

2006 Apr Journal of Biological Chemistry Ohio State University Comprehensive Cancer Center:  Chung-Wai Shiau, Jui-Wen Huang, Da-Sheng Wang, Chih-Cheng Yang, Chia-Hui Lin and Chenglong Li: Vitamin E succinate, or alpha tocopheryl succinate kills cancer cells by causing them to undergo apoptosis by blocking a protein called Bcl-xL


Maitake Mushroom Powder (Grifola frondosa)

Food Reviews International, 11(1), 135-149 (1995): T Mizuno and C Zhuang: Maitake, Grifola Frondosa: Pharmacological Effects.
 Molecular and Cellular Biochemistry. 2002;237129-237136: Talpur NA, Echard BW, Fan AY, Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains.

Journal of Immunology. 2004;173:797-806:Hong F, Yan J, Baran JT, et al. Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models.
 Journal of Agricultural and Food Chemistry 2006 Oct 4;54(20):7564-9.Lin JT, Liu WH: omicron-Orsellinaldehyde from the Submerged Culture of the Edible Mushroom Grifola frondosa Exhibits Selective Cytotoxic Effect Against Hep 3B Cells Through Apoptosis..

American Journal ofChinese Medicine.[#2008-02]  2008;36(2):265-85. Lo HC, Hsu TH, Chen CY: Submerged culture mycelium and broth of Grifola frondosa improve glycemic responses in diabetic rats.


Omega 3 fatty acids:

  • Cardiovascular benefits:

Journal of Veterinary Internal Medicine: 2006 Sep-Oct;20(5):1116-26.Freeman LM, Rush JE, Markwell PJ. Effects of dietary modification in dogs with early chronic valvular disease.

Canadian Journal of Physiology and Pharmacology (Canada), 1997, 75/3 (234-239):Simopoulos A.P:omega3 fatty acids in the prevention-management of cardiovascular disease

Circulation. 1999 May 11;99(18):2452-7:  Billman GE, Kang JX, Leaf A: Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs.

  • Immune benefits:

Veterinary Therapeutics 2005 Spring;6(1):29-42 :Filburn CR, Griffin D: Canine plasma and erythrocyte response to a docosahexaenoic acid-enriched supplement: characterization and potential benefits.

American Journal of Veterinary Research 1998; 59:859-863:Mooney MA, Vaughn DM, Reinhart GA, Powers RD, Wright JC, Hoffman CE, Swaim SF, Baker HJ: Evaluation of the effects of n-3 fatty acid-containing diets on the inflammatory stage of wound healing in dogs.

Journal of Nutrition 1997;127:1198-1205:Wander RC, Hall JA, Gradin JL, Du S-H, Jewell DE: The ratio of dietary (n-6) to (n-3) fatty acids influences immune system function, eicosanoid metabolism, lipid peroxidation and vitamin E status in aged dogs.

Veterinary Immunology and Immunopathology1999 Aug 2;69(2-4):165-83:Kearns RJ, Hayek MG, Turek JJ, Meydani M, Burr JR, Greene RJ, Marshall CA, Adams SM, Borgert RC, Reinhart GA: Effect of age, breed and dietary omega-6 (n-6): omega-3 (n-3) fatty acid ratio on immune function, eicosanoid production, and lipid peroxidation in young and aged dogs.

  • Dermatalogical Support (also see immune benefits)

American Journal of Veterinary Research 1998; 59:859-863:Mooney MA, Vaughn DM, Reinhart GA, Powers RD, Wright JC, Hoffman CE, Swaim SF, Baker HJ: Evaluation of the effects of n-3 fatty acid-containing diets on the inflammatory stage of wound healing in dogs.

Vet Rec. 1999 Apr 10;144(15):405-7: Harvey RG. A blinded, placebo-controlled study of the efficacy of borage seed oil and fish oil in the management of canine atopy.




Green Tea Extract (GTE) :

American Journal of Clinical Nutrition 2000; 71(6 Suppl):1698S–1702S Mukhtar H, Ahmad N. Tea polyphenols: Prevention of cancer and optimizing health. 

Journal of Agricultural and Food Chemistry  2004;52(11):3661-5.Vinson JA, Teufel K, Wu N: Green and black teas inhibit atherosclerosis by lipid, antioxidant, and fibrinolytic mechanisms.

American Journal of Clinical Nutrition 2004; 80(6):1558–1564:  SM, Niu Y, Lee NH, et al. Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement

Journal of Nutrition 2003; 133(10):3262S–3267SLambert JD, Yang CS. Mechanisms of cancer prevention by tea constituents.
Leukemia(journal) 2000;14:1477-1482:  Bertolini F, Fusetti L, Rabascio C et al. Inhibition of angiogenesis and induction of endothelial and tumor cell apoptosis by green tea in animal models of human high-grade non-Hodgkin's lymphoma.  

Experimental Gerontology 2008 Mar;43(3):176-83. Epub 2007 Nov 7: Senthil Kumaran V, Arulmathi K, Srividhya R, Kalaiselvi P: Repletion of antioxidant status by EGCG and retardation of oxidative damage induced macromolecular anomalies in aged rats.

International Heart Journal: 2007 Nov;48(6):725-32: Inami S, Takano M, Yamamoto M, Murakami D, Tajika K, Yodogawa K, Yokoyama S, Ohno N, Ohba T, Sano J, Ibuki C, Seino Y, Mizuno K.Tea catechin consumption reduces circulating oxidized low-density lipoprotein.


Raspberry Seed Extract:

http://www.ag.ohio-state.edu/~sfgnet/ellagic.html

Salk Institute for Biological Studies, La Jolla, California, USA. 1998 Sep;42(9):2245-53: Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells.

Federation of European Biochemical Societies (FEBS) Letters  2003 Jun 5;544(1-3):252-7: Atalay M, Gordillo G, Roy S, Rovin B, Bagchi D, Bagchi M, Sen CK: Anti-angiogenic property of edible berry in a model of hemangioma.

Carcinogenesis 4:1651-1653, 1983.Lesca, P: Protective effects of ellagic acid and other plant phenols on benzo(a)pyrene-induced neoplasia in mice.

Japan Journal of Cancer Research (Gann) 79:1297-1303, 1988.: Tanaka, T; Iwata, H; Niwa, K; Mori, Y; Mori, H: Inhibitory effect of ellagic acid on N-2-fluoenylacetamide-induced liver carcinogenesis in male AC1/N rats.

Carcinogenesis 6:1127-1133, 1985: Chang, RL, Hùang, MT; Wood, AW; Wong, CQ; Newmark, HL; Yagi H; Sayer, JM; Conney, AH: Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo(a)pyrene and (")-78ß,8a-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene on mouse skin and in the newborn mouse.

Anticancer Research (journal of)  2001 Nov-Dec;21(6A):3903-8. Festa F, Aglitti T, Duranti G, Ricordy R, Perticone P, Cozzi R. Strong antioxidant activity of ellagic acid in mammalian cells in vitro revealed by the comet assay.
Nutrition and Cancer 1992;18:181-9: Boukharta M, Jalbert G, Castonguay A. Biodistribution of ellagic acid and dose-related inhibition of lung tumorigenesis in A/J mice.

Xenobiotica 1980;10:247-56 Doyle B, Griffiths LA. The metabolism of ellagic acid in the rat.


Oligomeric Proanthocyanidins (GSE and Pine Bark Extract)

  • Antioxidant benefits:

Plant Med Phytother 1989; 4:267-74: Meunier M, Duroux E, Bastide P. Free-radical scavenger activity of procyanidolic oligomers and anthocyanosides with respect to superoxide anion and lipid peroxidation.

Biotechnol Ther 1994; 5:117-26:Rong Y, Li L, Shah V, Lau BH. Pycnogenol protects vascular endothelial cells from t-butyl hydroperoxide induced oxidant injury.

Redox Report 1997; 3:219-24:Wei Z, Peng Q, Lau B. Pycnogenol enhances endothelial cell antioxidant defenses.


FEBS Lett 1998; 431:315-8: Virgili F, Kim D, Packer L. Procyanidins extracted from pine bark protect alphatocopherol in ECV 304 endothelial cells challenged by activated RAW 264.7 macrophages: role of nitric oxide and peroxynitrite.


Drug Devel Industr Pharm 1998; 24:139-44Nelson A, Lau B, IDe N, Rong Y. Pycnogenol inhibits macrophage oxidative burst, lipoprotein oxidation, and hydroxyl radical induced DNA damage.

    Increases resistance to joint degradation:
Path Biol 1990; 38:601-7: Robert A, Groult N, Six C, Robert L. Study of the effect of procyanidolic oligomers on mesenchymal cells in culture. II Attachment of elastic fibers to the cells.

Path 1990; Biol:6. Robert L, Godeau G, Gavignet-Jeannin C, Groult N, Six C, Robert A. Action of procyanidolic oligomers on vascular permeability. A study by quantitative morphology.

  • Immune benefits:

Life Science 1996; 58:87-96: Cheshier JE, Ardestani-Kaboudanian S, Liang B, et al. Immunomodulation by pycnogenol in retrovirus-infected or ethanol-fed mice.

Free Radical Biological Medicine 2000;28:219-27: Bito T, Roy S, Sen CK, Packer L. Pine bark extract pycnogenol downregulates IFN-gamma-induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression.

Cellular Molecular Life Sci 1998;54:1168-72Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice.


Cysteine
 
FASEB J. 11:1077-1089: Droge and Holm (1997)Cysteine and glutathione in catabolic conditions and immunological dysfunction.

Alt Med Rev 1998;3(2):114-127: Gregory S. Kelly, N.D. Clinical Applications of N-acetylcysteine

International Immuninology. (United Kingdom), 1993, 5/1 (97-101): N-Acetylcysteine enhances T cell functions and T cell growth in culture

FASEB (UNITED STATES) Apr 1 1994, 8 (6) p448-51 Effect of glutathione depletion and oral N-acetyl-cysteine treatment on CD4+ and CD8+ cells.

Clinical Immunology Immunopathology (UNITED STATES) Jun 1994, 71 (3) p333-7 Inhibition with N-acetylcysteine of enhanced production of tumor necrosis factor in streptozotocin-induced diabetic rats.


Coenzyme Q-10:

  • Neurological benefits:

Proceedings of the NAtional Academy of Sciences (USA:MA Gen and Hrvad med schools)1998 Jul 21;95(15):8892-7: Matthews RT, Yang L, Browne S, Baik M, Beal MF: Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects.

Free Radic Res. 2002 Apr;36(4):455-60: Coenzyme Q10 as a possible treatment for neurodegenerative diseases.

  • Immune benefits:

Journal of Refractive Surgery. 2002 Mar-Apr;18(2):135-9: Brancato R, Fiore T, Papucci L, Schiavone N, Formigli L, Orlandini SZ, Gobbi PG, Carones F, Donnini M, Lapucci A, Capaccioli S. Concomitant effect of topical ubiquinone Q10 and vitamin E to prevent keratocyte apoptosis after excimer laser photoablation in rabbits

Asian Pacific journal of cancer prevention (APJCP) 7 (4): 599–603: Sakano, K; Takahashi, M; Kitano, M; Sugimura, T; Wakabayashi, K (2006). Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats

  • Cardiovacular benefits:

Pharmacotherapy. 2001 Jul;21(7):797-806: Tran MT, Mitchell TM, Kennedy DT, Giles JT. Role of coenzyme Q10 in chronic heart failure, angina, and hypertension.

Journal of Association of Physicians India. 1998 Mar;46(3):299-306: Singh RB, Niaz MA, Rastogi V, Rastogi SS. Coenzyme Q in cardiovascular disease.

  • Periodontal benefits:

Research communications in chemical pathology and pharmacology 14 (4): 715–9 Wilkinson, EG; Arnold, RM; Folkers, K (1976):  Bioenergetics in clinical medicine. VI. adjunctive treatment of periodontal disease with coenzyme Q10

Journal of Dental Health (1993): McRee JT, Hanioka T, Shizukuishi S, Folkers K  Therapy with coenzyme Q10 for patients with periodontal disease